BDBM50191357 CHEMBL3903492

SMILES Cc1c2cc(cnc2[nH]n1)C(=O)N3CCC[C@H]3c4ccc(cc4)Cl

InChI Key InChIKey=ODRITQGYYWHQGM-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50191357   

TargetCyclin-dependent kinase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50: 9nMAssay Description:Inhibition of CDK8 in human COLO205 cells expressing APC mutant assessed as suppression of WNT pathway by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 alpha(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50: 691nMAssay Description:Inhibition of GSK-3alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50: 8nMAssay Description:Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50: 32nMAssay Description:Inhibition of CDK8 in human LS174T cells expressing beta-catenin mutant assessed as suppression of WNT pathway by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50: 52nMAssay Description:Inhibition of CDK8 in human PA1 cells assessed as suppression of WNT3a ligand-induced WNT pathway by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent dopamine transporter(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50: 8.50E+3nMAssay Description:Displacement of [3H]BTCP from human recombinant dopamine transporter expressed in CHO cells after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCyclin-C(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CDK8 in human Jurkat cells assessed as inhibition of STAT1 phosphorylation at S727 residue measured after 24 hrs by Western blot ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)