BDBM50190976 (1S)-[2-{4-[2-methyl-3-(2-methoxy-4-chlorophenyl)propionyl]-1-piperazinyl}-5-(trifluoromethyl)phenyl]-3-methylbutylamine::1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluoromethyl)phenyl)piperazin-1-yl)-3-(4-chloro-2-methoxyphenyl)-2-methylpropan-1-one::CHEMBL377231

SMILES COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(CC1)c1ccc(cc1[C@@H](N)CC(C)C)C(F)(F)F

InChI Key InChIKey=HQACQGVVMYJUAG-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50190976   

TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190976(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataIC50: 1.70E+3nMAssay Description:Activity at MC4R assessed as inhibition of alpha MSH-stimulated cAMP production in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190976(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataIC50: 1.70E+3nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190976(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190976(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190976(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  86nMAssay Description:Displacement of [125I]NDP-MSH from human MC5R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190976(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  86nMAssay Description:Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190976(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  320nMAssay Description:Displacement of [125I]NDP-MSH from human MC3R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190976(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  320nMAssay Description:Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed