BDBM50190975 (1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]-1-piperazinyl}-5-methylphenyl)-3-methylbutylamine::(R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-methylphenyl)piperazin-1-yl)-3-(4-chlorophenyl)-2-methylpropan-1-one::CHEMBL213122

SMILES CC(C)C[C@H](N)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1

InChI Key InChIKey=RZLPZBLBQNNVLZ-UHFFFAOYSA-N

Data  8 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50190975   

TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataIC50: 560nMAssay Description:Activity at MC4R assessed as inhibition of alpha MSH-stimulated cAMP production in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataIC50: 570nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [125I]NDP-MSH from human MC5R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [125I]NDP-MSH from human MC3R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataKi:  3.10E+3nMAssay Description:Displacement of [125I]NDP-MSH from human MC1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataKi:  3.10E+3nMAssay Description:Displacement of [125I]NDPMSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed