BDBM50190612 (2Z)-4-[1-(4-fluoro-benzyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-but-2-enoic acid methyl ester::CHEMBL2070203::CHEMBL208722

SMILES COC(=O)C(=O)CC(=O)c1cccn1Cc1ccc(F)cc1

InChI Key InChIKey=BFBAOTVZHHOALZ-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50190612   

TargetIntegrase(Human immunodeficiency virus type 1)
Università

Curated by ChEMBL
LigandPNGBDBM50190612(CHEMBL208722 | CHEMBL2070203 | (2Z)-4-[1-(4-fluoro...)
Affinity DataIC50: 1.87E+5nMAssay Description:Inhibition of HIV1 integrase 3' processing activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Università

Curated by ChEMBL
LigandPNGBDBM50190612(CHEMBL208722 | CHEMBL2070203 | (2Z)-4-[1-(4-fluoro...)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50190612(CHEMBL208722 | CHEMBL2070203 | (2Z)-4-[1-(4-fluoro...)
Affinity DataKi:  3.27E+3nMAssay Description:Inhibition of human CA2 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50190612(CHEMBL208722 | CHEMBL2070203 | (2Z)-4-[1-(4-fluoro...)
Affinity DataKi:  5.53E+3nMAssay Description:Inhibition of human CA1 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50190612(CHEMBL208722 | CHEMBL2070203 | (2Z)-4-[1-(4-fluoro...)
Affinity DataKi:  6.86E+3nMAssay Description:Inhibition of human CA9 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50190612(CHEMBL208722 | CHEMBL2070203 | (2Z)-4-[1-(4-fluoro...)
Affinity DataKi:  8.51E+3nMAssay Description:Inhibition of human CA12 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed