BDBM50190597 23-N-(carbocinnamyloxy)-3alpha,7alpha-dihydroxy-24-nor-5beta-cholan-23-amine::CHEMBL212641

SMILES C[C@H](CCNC(=O)OC\C=C\c1ccccc1)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3CC[C@]12C

InChI Key InChIKey=CSHFDEXMEUXQFY-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50190597   

TargetBile acid receptor(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50190597(23-N-(carbocinnamyloxy)-3alpha,7alpha-dihydroxy-24...)
Affinity DataEC50:  900nMAssay Description:Agonist activity at human GST-fused FXR LBD assessed as coactivator interaction with receptor ligand binding domain by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50190597(23-N-(carbocinnamyloxy)-3alpha,7alpha-dihydroxy-24...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed