BDBM50190524 3-(2-methylpropyl)-9-(4-phenoxyphenylmethyl)-1-propyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride::CHEMBL557150::rac-3-Isobutyl-9-(4-phenoxybenzyl)-1-propyl-1,4,9-triazaspiro[5.5]undecane-2,5-dione hydrochloride

SMILES CCCN1C(=O)C(CC(C)C)NC(=O)C11CCN(Cc2ccc(Oc3ccccc3)cc2)CC1

InChI Key InChIKey=KUHZERKUYOBQDZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50190524   

TargetC-C chemokine receptor type 5(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190524(rac-3-Isobutyl-9-(4-phenoxybenzyl)-1-propyl-1,4,9-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190524(rac-3-Isobutyl-9-(4-phenoxybenzyl)-1-propyl-1,4,9-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of radio-isotope labeled MCP1 binding to human recombinant CCR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190524(rac-3-Isobutyl-9-(4-phenoxybenzyl)-1-propyl-1,4,9-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of radio-isotope labeled SDF1-alpha binding to human recombinant CXCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190524(rac-3-Isobutyl-9-(4-phenoxybenzyl)-1-propyl-1,4,9-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity against human recombinant CCR4 expressed in CHO cells assessed as inhibition of human MCD-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190524(rac-3-Isobutyl-9-(4-phenoxybenzyl)-1-propyl-1,4,9-...)
Affinity DataIC50: 500nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190524(rac-3-Isobutyl-9-(4-phenoxybenzyl)-1-propyl-1,4,9-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity against human recombinant CXCR4 expressed in CHO cells assessed as inhibition of human SDF1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190524(rac-3-Isobutyl-9-(4-phenoxybenzyl)-1-propyl-1,4,9-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity against human recombinant CCR2 expressed in CHO cells assessed as inhibition of human MCP1-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50190524(rac-3-Isobutyl-9-(4-phenoxybenzyl)-1-propyl-1,4,9-...)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed