BDBM50189751 3-[5-(2,4-dioxothiazolidin-5-ylidenemethyl)furan-2-yl]-4-hydroxybenzonitrile::CHEMBL378999

SMILES Oc1ccc(cc1-c1ccc(\C=C2/SC(=O)NC2=O)o1)C#N

InChI Key InChIKey=NPCCZSIFYWKTIW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50189751   

LigandPNGBDBM50189751(3-[5-(2,4-dioxothiazolidin-5-ylidenemethyl)furan-2...)
Affinity DataIC50: 40nMAssay Description:Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50189751(3-[5-(2,4-dioxothiazolidin-5-ylidenemethyl)furan-2...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189751(3-[5-(2,4-dioxothiazolidin-5-ylidenemethyl)furan-2...)
Affinity DataIC50: 220nMAssay Description:Inhibition of human PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed