BDBM50189744 (Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione::CHEMBL379156

SMILES Oc1cc(F)ccc1-c1ccc(\C=C2/SC(=O)NC2=O)o1

InChI Key InChIKey=OYYVWNDMOQPMGE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50189744   

LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50: 33nMAssay Description:Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Serono Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MKK7betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Serono Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Serono Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50: 940nMAssay Description:Inhibition of human PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human PI3Kgamma by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed