BDBM50189495 CHEMBL3827758

SMILES COC1CN(C1)C(=O)c1ccc2c(N)ncc(-c3ccc(cc3)-c3cnn(C)c3)c2c1

InChI Key InChIKey=VYWUTAQQVFMHBW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50189495   

TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189495(CHEMBL3827758)
Affinity DataIC50: 21nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMed
TargetCyclin-C(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189495(CHEMBL3827758)
Affinity DataIC50: 33nMAssay Description:Binding affinity to human CDK8 (1 to 464 residues)/cyclin C (1 to 283 residues) by reporter probe displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMed
TargetCyclin-C(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189495(CHEMBL3827758)
Affinity DataIC50: 12nMAssay Description:Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMed