BDBM50188457 1-(2-chloroethyl)-1-nitroso-3-methyl-3-{[4-(3-bromophenyl)amino]quinazolin-6-yl}urea::CHEMBL210893

SMILES CN(C(=O)N(CCCl)N=O)c1ccc2ncnc(Nc3cccc(Br)c3)c2c1

InChI Key InChIKey=ZLJXNOJTRKIARN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50188457   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50188457(1-(2-chloroethyl)-1-nitroso-3-methyl-3-{[4-(3-brom...)
Affinity DataIC50: 3.06E+3nMAssay Description:Inhibition of serum-stimulated proliferation of mouse ERBB2 transfected NIH3T3 cell line after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50188457(1-(2-chloroethyl)-1-nitroso-3-methyl-3-{[4-(3-brom...)
Affinity DataIC50: 294nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed