BDBM50184879 CHEMBL424676::dimethyl-{2-[(4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-2-pyridinyl}phenyl)oxy]ethyl}amine

SMILES CN(C)CCOc1ccc(cc1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1

InChI Key InChIKey=VYTQMUCONGRNBX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50184879   

TargetTransforming growth factor beta-1 proprotein(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50184879(dimethyl-{2-[(4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184879(dimethyl-{2-[(4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-...)
Affinity DataIC50: 15nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed