BDBM50184490 3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-benzoimidazol-1-yl]-propan-1-ol::CHEMBL203619

SMILES OCCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1

InChI Key InChIKey=SYCWRTUPLPDKDX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50184490   

LigandPNGBDBM50184490(3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...)
Affinity DataIC50: 708nMAssay Description:Inhibition of MLK7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184490(3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...)
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184490(3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...)
Affinity DataIC50: 79nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTGF-beta receptor type-2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184490(3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...)
Affinity DataIC50: 352nMAssay Description:Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed