BDBM50184488 6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-1Hbenzoimidazole::CHEMBL382838

SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2nc[nH]c2c1

InChI Key InChIKey=YIACYWZAPISCDQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50184488   

LigandPNGBDBM50184488(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of MLK7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184488(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Affinity DataIC50: 15nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184488(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of cytochrome P450 2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184488(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184488(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed