BDBM50183966 4-(8-(benzo[d][1,3]dioxol-5-ylmethyl)-8-aza-bicyclo[3.2.1]octan-3-ylamino)-6-chloro-1-(2,2,2-trifluoroethyl)quinazolin-2(1H)-one::CHEMBL205493

SMILES FC(F)(F)Cn1c2ccc(Cl)cc2c(NC2CC3CCC(C2)N3Cc2ccc3OCOc3c2)nc1=O

InChI Key InChIKey=TUISOQBOQRFWFJ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50183966   

TargetMelanin-concentrating hormone receptor 1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183966(4-(8-(benzo[d][1,3]dioxol-5-ylmethyl)-8-aza-bicycl...)
Affinity DataIC50: 31nMAssay Description:Inhibition of MCH-mediated calcium release in whole IMR32 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183966(4-(8-(benzo[d][1,3]dioxol-5-ylmethyl)-8-aza-bicycl...)
Affinity DataIC50: 4nMAssay Description:Displacement of [125I]MCH from MCHr1 expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183966(4-(8-(benzo[d][1,3]dioxol-5-ylmethyl)-8-aza-bicycl...)
Affinity DataKi:  120nMAssay Description:Binding affinity to hERG stably transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed