BDBM50183791 CHEMBL209295::isopropyl (3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl(4-(methylsulfonyl)phenyl)carbamate

SMILES CC(C)OC(=O)N(Cc1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)C#N)c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=QGELAKDHJSCTHV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50183791   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183791(isopropyl (3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)...)
Affinity DataIC50: 80nMAssay Description:Ability to block TNFalpha release through inhibition of PDE4 in LPS-stimulated human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183791(isopropyl (3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183791(isopropyl (3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human GST-PDE4AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183791(isopropyl (3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human GST-PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183791(isopropyl (3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human GST-PDE4CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed