BDBM50183517 CHEMBL3823859::US11773085, Compound B50

SMILES COc1cc(cc(OC)c1CN(C)C)-c1cn(C)c(=O)c2ccncc12

InChI Key InChIKey=UPTRHHQDRFTXBF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50183517   

TargetBromodomain-containing protein 7(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50183517(CHEMBL3823859 | US11773085, Compound B50)
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of human N-terminal GST-tagged BRD7 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50183517(CHEMBL3823859 | US11773085, Compound B50)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged BRD2-BD1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50183517(CHEMBL3823859 | US11773085, Compound B50)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged BRD4-BD2 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50183517(CHEMBL3823859 | US11773085, Compound B50)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged BRD4-BD1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50183517(CHEMBL3823859 | US11773085, Compound B50)
Affinity DataIC50: 128nMAssay Description:Inhibition of human N-terminal GST-tagged BRD9 isoform 1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 9 [133-239](Human)
Foghorn Therapeutics

US Patent
LigandPNGBDBM50183517(CHEMBL3823859 | US11773085, Compound B50)
Affinity DataIC50: 55nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2023
Entry Details
Go to US Patent