BDBM50182695 CHEMBL202360::N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-propynamide

SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)C#C)cc23)c1

InChI Key InChIKey=RHNCTEJANSMRNV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50182695   

TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182695(N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-prop...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of EGF stimulated human erbB1 autophosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182695(N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-prop...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182695(N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-prop...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of erbB2 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182695(N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-prop...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of erbB1 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed