BDBM50182555 1-(4-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one::CHEMBL201960::pyrovalerone

SMILES CCCC(N1CCCC1)C(=O)c1ccc(C)cc1

InChI Key InChIKey=SWUVZKWCOBGPTH-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50182555   

TargetSodium-dependent dopamine transporter(Human)
Duquesne University Mylan School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50182555(pyrovalerone | 1-(4-methylphenyl)-2-pyrrolidin-1-y...)
Affinity DataIC50: 32nMAssay Description:Inhibition of [3H]dopamine uptake at human dopamine transporter expressed in mouse N2A cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Duquesne University Mylan School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50182555(pyrovalerone | 1-(4-methylphenyl)-2-pyrrolidin-1-y...)
Affinity DataIC50: 52nMAssay Description:Inhibition of [3H] dopamine uptake into human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50182555(pyrovalerone | 1-(4-methylphenyl)-2-pyrrolidin-1-y...)
Affinity DataIC50: 2.78E+3nMAssay Description:Inhibition of [3H] serotonin uptake into human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50182555(pyrovalerone | 1-(4-methylphenyl)-2-pyrrolidin-1-y...)
Affinity DataIC50: 28.3nMAssay Description:Inhibition of [3H] norepinephrine uptake into human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Duquesne University Mylan School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50182555(pyrovalerone | 1-(4-methylphenyl)-2-pyrrolidin-1-y...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]WIN-35428 from human dopamine transporter expressed in mouse N2A cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Duquesne University Mylan School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50182555(pyrovalerone | 1-(4-methylphenyl)-2-pyrrolidin-1-y...)
Affinity DataKi:  21.4nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50182555(pyrovalerone | 1-(4-methylphenyl)-2-pyrrolidin-1-y...)
Affinity DataKi:  195nMAssay Description:Displacement of [125I]RTI-55 from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50182555(pyrovalerone | 1-(4-methylphenyl)-2-pyrrolidin-1-y...)
Affinity DataKi:  3.77E+3nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed