BDBM50182212 7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclopentyl)-3-(4-methoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

SMILES COc1ccc(cc1)N1Cc2cnc(Nc3ccc(F)cc3)nc2N(C2CC[C@@H](O)C2)C1=O

InChI Key InChIKey=KXEMINRANVTICS-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50182212   

TargetProtein kinase C alpha type(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibitory activity against PKC alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 9.01E+3nMAssay Description:Inhibitory activity against PKAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 1/2/3/4(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 92nMAssay Description:Inhibitory activity against recombinant human FGFRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 83nMAssay Description:Inhibitory activity against recombinant human PDGFRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 466nMAssay Description:Inhibitory activity against FynMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibitory activity against PKC deltaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against recombinant human KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibitory activity against AKTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibitory activity against EphB3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibitory activity against SGKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibitory activity against Erk2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 545nMAssay Description:Inhibitory activity against recombinant human EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed