BDBM50181926 2-{4-[Bis-(4-dimethylcarbamoyl-phenyl)-methoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid::CHEMBL203449

SMILES CN(C)C(=O)c1ccc(cc1)C(Oc1ccc(-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(F)c1)c1ccc(cc1)C(=O)N(C)C

InChI Key InChIKey=NLWCQULRIYJSJI-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50181926   

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50181926(2-{4-[Bis-(4-dimethylcarbamoyl-phenyl)-methoxy]-2-...)
Affinity DataIC50: 640nMAssay Description:Inhibitory activity against HCV 1b NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50181926(2-{4-[Bis-(4-dimethylcarbamoyl-phenyl)-methoxy]-2-...)
Affinity DataIC50: 950nMAssay Description:Inhibitory activity against HCV 1a NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50181926(2-{4-[Bis-(4-dimethylcarbamoyl-phenyl)-methoxy]-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA polymerase beta(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50181926(2-{4-[Bis-(4-dimethylcarbamoyl-phenyl)-methoxy]-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50181926(2-{4-[Bis-(4-dimethylcarbamoyl-phenyl)-methoxy]-2-...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of HCV RNA replication in Huh5-2 cells after 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed