BDBM50181532 CHEMBL201307::N-(3-fluorophenyl)-2-(2-(7-(3-(4-(hydroxymethyl)piperidin-1-yl)propoxy)-6-methoxyquinazolin-4-ylamino)thiazol-5-yl)acetamide::N-(3-fluorophenyl)-2-{2-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1,3-thiazol-5-yl}acetamide::N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidin-1-yl)propoxy)-6-methoxyquinazolin-4-ylamino)thiazol-5-yl)acetamide

SMILES COc1cc2c(Nc3ncc(CC(=O)Nc4cccc(F)c4)s3)ncnc2cc1OCCCN1CCC(CO)CC1

InChI Key InChIKey=QNJAKUMXJFWQOG-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50181532   

TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 7nMAssay Description:Inhibition of aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibitory activity against CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against human hERG receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against JNK1alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibitory activity against IGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibitory activity against CSKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory activity against FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 800nMAssay Description:Inhibitory activity against EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against p38-alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 800nMAssay Description:Inhibition of EGFR kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1/2/3/4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory activity against FGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against PKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Aurora A kinase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed