BDBM50179663 1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2-ylidene)urea::CHEMBL204115

SMILES Cn1c(O)cnc1NC(=O)Nc1cccc(Cl)c1

InChI Key InChIKey=DGPGUJUKHBGADZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50179663   

TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179663(1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179663(1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179663(1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...)
Affinity DataIC50: 58nMAssay Description:Negative allosteric modulation of human mGlu5a receptor expressed in HEK293 cells co-expressing EAAC1 assessed as inhibition of quisqualate-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179663(1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...)
Affinity DataIC50: 2.30E+3nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details Article
PubMed