BDBM50179139 (R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(5-oxo-6-oxa-4-aza-spiro[2.4]hept-4-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide::CHEMBL204308

SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(CN3C(=O)OCC33CC3)(CC2)C2CCCCC2)cc1

InChI Key InChIKey=LDHOENQCWMSQTE-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50179139   

TargetMelanocortin receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179139((R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  620nMAssay Description:Activity against human MC5R by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179139((R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  990nMAssay Description:Activity against human MC3R by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179139((R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50: 4.60nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC4R expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179139((R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50: 490nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179139((R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50: 2.40E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC1BR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179139((R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  2.60E+3nMAssay Description:Activity against human MC1BR by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179139((R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  6.10nMAssay Description:Activity against human MC4R by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179139((R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50: 170nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed