BDBM50177817 2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]amino}-5-[(penta fluorobenzyl)oxy]benzo-1,4-quinone::CHEMBL370356

SMILES COc1cc2c(N=C3CC(=O)C(OCc4c(F)c(F)c(F)c(F)c4F)=CC3=O)ncnc2cc1OCCCN1CCCC1

InChI Key InChIKey=OUZYELZMZNWQIY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50177817   

TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177817(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177817(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177817(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed