BDBM50177547 CHEMBL381717::N,N-dimethyl-3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-amine

SMILES CN(C)CCCOc1ccc(CN2CCCCC2)cc1

InChI Key InChIKey=QUUUOVGZDVVVGL-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50177547   

TargetCytochrome P450 2D6(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177547(N,N-dimethyl-3-(4-(piperidin-1-ylmethyl)phenoxy)pr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 by human liver microsome assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177547(N,N-dimethyl-3-(4-(piperidin-1-ylmethyl)phenoxy)pr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50177547(N,N-dimethyl-3-(4-(piperidin-1-ylmethyl)phenoxy)pr...)
Affinity DataKi:  3nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177547(N,N-dimethyl-3-(4-(piperidin-1-ylmethyl)phenoxy)pr...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from guinea pig histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50177547(N,N-dimethyl-3-(4-(piperidin-1-ylmethyl)phenoxy)pr...)
Affinity DataKi:  45nMAssay Description:Displacement of N-[3H]methylhistamine from rat histamine H3 receptor in rat cortical hemispheresMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed