BDBM50175765 1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-(3-hydroxypropoxy)phenyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)urea hydrochloride::CHEMBL454397::CHEMBL539597::CHEMBL573970

SMILES CCCCn1c2ncccc2c(-c2cccc(OCCCO)c2)c(NC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)c1=O

InChI Key InChIKey=HNRUUMLUBDTZHX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50175765   

TargetSterol O-acyltransferase 1(Human)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50175765(CHEMBL454397 | CHEMBL539597 | CHEMBL573970 | 1-(4-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50175765(CHEMBL454397 | CHEMBL539597 | CHEMBL573970 | 1-(4-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50175765(CHEMBL454397 | CHEMBL539597 | CHEMBL573970 | 1-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat macrophages ACATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50175765(CHEMBL454397 | CHEMBL539597 | CHEMBL573970 | 1-(4-...)
Affinity DataIC50: 21nMAssay Description:Inhibitory activity against ACAT in rat macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed