BDBM50175535 2-(4-Butoxy-benzenesulfonylamino)-N-hydroxy-acetamide::CHEMBL197842

SMILES CCCCOc1ccc(cc1)S(=O)(=O)NCC(=O)NO

InChI Key InChIKey=WHHAEBOHMHRZGW-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50175535   

LigandPNGBDBM50175535(2-(4-Butoxy-benzenesulfonylamino)-N-hydroxy-acetam...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human recombinant ADAMTS4 expressed in HEk293 cells using FAM-AEwLQGRPISIAK-TAMRA as substrate measured for 15 mins by fluorometric ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50175535(2-(4-Butoxy-benzenesulfonylamino)-N-hydroxy-acetam...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human recombinant ADAMTS5 expressed in HEK293 cells using Abz-TESEwSRGAIY-Dpa-KK as substrate measured for 2 hrs by fluorometric analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175535(2-(4-Butoxy-benzenesulfonylamino)-N-hydroxy-acetam...)
Affinity DataIC50: 920nMAssay Description:Inhibitory concentration against (MMP-1) matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50175535(2-(4-Butoxy-benzenesulfonylamino)-N-hydroxy-acetam...)
Affinity DataIC50: 71nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCollagenase 3(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50175535(2-(4-Butoxy-benzenesulfonylamino)-N-hydroxy-acetam...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant MMP13 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50175535(2-(4-Butoxy-benzenesulfonylamino)-N-hydroxy-acetam...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human recombinant MMP2 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175535(2-(4-Butoxy-benzenesulfonylamino)-N-hydroxy-acetam...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human recombinant MMP1 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed