BDBM50174491 (Z)-2-Hydroxy-4-oxo-4-m-tolyl-but-2-enoic acid::CHEMBL370131::Sacchettini_5

SMILES Cc1cccc(c1)C(=O)CC(=O)C(O)=O

InChI Key InChIKey=WJMYZRZUDQQIBC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50174491   

TargetMalate synthase G [C619A](Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
D3R/Abbott

LigandPNGBDBM50174491((Z)-2-Hydroxy-4-oxo-4-m-tolyl-but-2-enoic acid | C...)
Affinity DataIC50: 180nMAssay Description:DNTB-Coupled_Enzyme_AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50174491((Z)-2-Hydroxy-4-oxo-4-m-tolyl-but-2-enoic acid | C...)
Affinity DataIC50: 1.20E+4nMpH: 7.5Assay Description:Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed