BDBM50172138 CHEMBL3808443::US10040788, Example 1(a)::US10294221, Example 1(a)

SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccccc1

InChI Key InChIKey=YPVDEDXOCCSSBO-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50172138   

TargetGlutaminase kidney isoform, mitochondrial(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50172138(CHEMBL3808443 | US10040788, Example 1(a) | US10294...)
Affinity DataIC50: 63nMAssay Description:Inhibition of 6His-tagged GLS1 (63-669 residues) (unknown origin) expressed in Escherichia coli using glutamine as substrate after 15 mins by Glutama...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50172138(CHEMBL3808443 | US10040788, Example 1(a) | US10294...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of GLS1 in human PC3 cells assessed as cellular glutamate depletion levels after 6 hrs by Glutamate Oxidase/ AmplexRed coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50172138(CHEMBL3808443 | US10040788, Example 1(a) | US10294...)
Affinity DataIC50: 62.8nMpH: 7.8Assay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50172138(CHEMBL3808443 | US10040788, Example 1(a) | US10294...)
Affinity DataIC50: 62.8nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50172138(CHEMBL3808443 | US10040788, Example 1(a) | US10294...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50172138(CHEMBL3808443 | US10040788, Example 1(a) | US10294...)
Affinity DataIC50: 3.33E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by Ionworks electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50172138(CHEMBL3808443 | US10040788, Example 1(a) | US10294...)
Affinity DataIC50: 63nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed