BDBM50172058 CHEMBL3805675

SMILES COc1cccc(c1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1

InChI Key InChIKey=OQUNFHUNFXVBPC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50172058   

TargetEpidermal growth factor receptor(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50172058(CHEMBL3805675)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of recombinant His6-tagged EGFR (unknown origin) cytoplasmic domain (645 to 1186 residues) autophosphorylation expressed in baculovirus in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Mouse)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50172058(CHEMBL3805675)
Affinity DataIC50: 2.28E+4nMAssay Description:Inhibition of mouse c-Raf assessed as reduction in human full length N-terminal His-tagged MEK1 phosphorylation pre-incubated for 1 hr before MEK1 ad...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Mouse)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50172058(CHEMBL3805675)
Affinity DataIC50: 2.62E+3nMAssay Description:Inhibition of mouse wild type BRAF assessed as reduction in human full length N-terminal His-tagged MEK1 phosphorylation pre-incubated for 1 hr befor...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed