BDBM50170221 CHEMBL3806189

SMILES CN1CCN(Cc2ccc(NC(=O)CNc3ccc(cc3F)-c3ccc(NC(=O)C4CC4)nc3)cc2C(F)(F)F)CC1

InChI Key InChIKey=CGMQSJXTBXHOTH-UHFFFAOYSA-N

Data  25 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50170221   

TargetCytochrome P450 2D6(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of cKIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 272nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 10nMAssay Description:Inhibition of ABL1 in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 280nMAssay Description:Inhibition of eIF4E phosphorylation in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 24nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 24nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 24nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 10nMAssay Description:Inhibition of ABL1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 10nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 200nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 10nMAssay Description:Inhibition of BCR fused full length human recombinant N-terminal His-tagged ABL (2 to 1130 residues) expressed in baculovirus expression system using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of human recombinant PDGFRbeta expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of human recombinant PDGFRalpha expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 272nMAssay Description:Inhibition of human recombinant FGFR2 expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of human recombinant c-KIT expressed in insect cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant RET expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant VEGFR2 expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant FLT3 expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 20nMAssay Description:Inhibition of full length human recombinant N-terminal His-tagged ABL (2 to 1130 residues) T315I mutant expressed in baculovirus expression system us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 200nMAssay Description:Inhibition of N-terminal GST-tagged MNK1 kinase domain (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed