BDBM50169052 CHEMBL3806235::US10442808, Example 54::US9815842, Example 54

SMILES FC(F)(F)c1cc(NC(=O)Nc2cnc3cc(Cl)nn3c2C2CCCO2)cnc1-n1nccn1

InChI Key InChIKey=JPJNJCRHXRRUBG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50169052   

TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50169052(CHEMBL3806235 | US9815842, Example 54 | US10442808...)
Affinity DataIC50: 0.0940nMAssay Description:Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2017
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50169052(CHEMBL3806235 | US9815842, Example 54 | US10442808...)
Affinity DataIC50: 0.00400nMAssay Description:Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2017
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50169052(CHEMBL3806235 | US9815842, Example 54 | US10442808...)
Affinity DataIC50: 0.00400nMAssay Description:IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
Go to US Patent

LigandPNGBDBM50169052(CHEMBL3806235 | US9815842, Example 54 | US10442808...)
Affinity DataIC50: 0.00400nMAssay Description:The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent