BDBM50168390 2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino]-N-methoxy-benzamide::CHEMBL192101

SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F

InChI Key InChIKey=OSPKANQURMXUIE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50168390   

TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168390(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1/2/3/4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168390(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168390(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168390(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human fibroblast growth factor receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed