BDBM50168389 CHEMBL195218::[4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid 3-methanesulfonyl-propyl ester

SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F

InChI Key InChIKey=ITQSJZWWFWDOKJ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50168389   

TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 100nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 0.0620nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2 (VEGFR-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 58nMAssay Description:Inhibition of human fibroblast growth factor receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human cyclin-dependent kinase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 62nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human platelet-derived growth factor receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition against human HER2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168389([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human epidermal growth factor receptor (HER-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed