BDBM50167073 CHEMBL3798017

SMILES COc1ccccc1OCCNC[C@@H](O)COc1cccc2[nH]c3ccccc3c12

InChI Key InChIKey=OGHNVEJMJSYVRP-UHFFFAOYSA-N

Data  6 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50167073   

TargetOrexin receptor type 2(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50167073(CHEMBL3798017)
Affinity DataIC50: 900nMAssay Description:Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50167073(CHEMBL3798017)
Affinity DataIC50: 2.30E+3nMAssay Description:Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50167073(CHEMBL3798017)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human CYP1B1 using 7-ethyl-O-resorufin as substrate incubated for 30 mins in presence of NADPH by EROD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDynamin-1(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50167073(CHEMBL3798017)
Affinity DataIC50: 3.49E+4nMAssay Description:Inhibition of phosphotidylserine liposome-stimulated Dynamin 1 (unknown origin) GTPase activity by malachite green assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetBeta-2 adrenergic receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50167073(CHEMBL3798017)
Affinity DataKi:  0.880nMAssay Description:Displacement of [3H]CGP12177 from human beta2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2017
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50167073(CHEMBL3798017)
Affinity DataKi:  0.880nMAssay Description:Displacement of [3H]-CGP-12177 from human beta2-adrenergic receptor expressed in CHO cells after 60 mins by radioligand competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Mouse)
Friedrich-Alexander University Erlangen-N£Rnberg (Fau)

Curated by ChEMBL
LigandPNGBDBM50167073(CHEMBL3798017)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]-CGP-12177 from murine beta1-adrenergic receptor expressed in HEK293T cells after 60 mins by radioligand competition binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50167073(CHEMBL3798017)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]spiperone from human D2S receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2017
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50167073(CHEMBL3798017)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50167073(CHEMBL3798017)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed