BDBM50166451 (R)-1-(2-fluoro-6-(methylsulfonyl)benzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione::3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-fluoro-6-methanesulfonyl-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-1H-pyrimidine-2,4-dione::CHEMBL364914

SMILES COc1cccc(c1F)-c1cn(Cc2c(F)cccc2S(C)(=O)=O)c(=O)n(C[C@H](N)c2ccccc2)c1=O

InChI Key InChIKey=GRKSCYLPVRPFEA-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50166451   

TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166451(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-fluoro-6-metha...)
Affinity DataIC50: 380nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166451(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-fluoro-6-metha...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity towards human gonadotropin-releasing hormone receptor (GNRHR) using GnRH peptide as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166451(3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-fluoro-6-metha...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to human GnRHRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed