BDBM50166286 (RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid::2-Amino-3-[5-(2-ethyl-2H-tetrazol-5-yl)-3-hydroxy-isoxazol-4-yl]-propionic acid::2-amino-3-(5-(2-ethyl-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid::CHEMBL370941

SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O

InChI Key InChIKey=RKKOVPYSRPVXQY-UHFFFAOYSA-N

Data  12 KI  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50166286   

TargetGlutamate receptor ionotropic, kainate 3(Rat)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataEC50:  3.50E+3nMAssay Description:In vitro activity at Ionotropic glutamate receptor using cortical wedge assays in rat brain synaptosomaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataEC50:  5.20E+4nMAssay Description:Agonist activity at GluR2Q expressed in HEK293 cells by Fluo-4/Ca2+ assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 4(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at GluR4 expressed in HEK293 cells by Fluo-4/Ca2+ assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataEC50:  1.80E+4nMAssay Description:Agonist activity at GluR3 expressed in HEK293 cells by Fluo-4/Ca2+ assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataEC50:  4.20E+4nMAssay Description:Agonist activity at GluR1 expressed in HEK293 cells by Fluo-4/Ca2+ assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 4(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi:  0.0440nMAssay Description:Displacement of [3H]AMPA from rat recombinant GluR4 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi:  0.0450nMAssay Description:Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]AMPA from rat recombinant GluR2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]SYM 2081 from rat recombinant GluR5 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 4(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi:  44.4nMAssay Description:Binding affinity for ionotropic Glutamate receptor AMPA 4 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi:  44.8nMAssay Description:Binding affinity for ionotropic Glutamate receptor AMPA 3 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi:  80.2nMAssay Description:Binding affinity for ionotropic Glutamate receptor AMPA 2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]KA from rat recombinant GluR6 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi:  145nMAssay Description:Binding affinity for ionotropic Glutamate receptor AMPA 1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi:  2.92E+3nMAssay Description:Binding affinity for kainate Glutamate receptor GluR5 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity for kainate Glutamate receptor GluR6 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed