BDBM50166283 CHEMBL192678::Methyl-5-[4-(methylsulfonyl)phenyl]-1-phenyl-1H-pyrrol-3-acetic Acid::[5-(4-Methanesulfonyl-phenyl)-2-methyl-1-phenyl-1H-pyrrol-3-yl]-acetic acid

SMILES Cc1c(CC(O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccccc1

InChI Key InChIKey=WJRHOGLBMOCHHB-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50166283   

TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50166283([5-(4-Methanesulfonyl-phenyl)-2-methyl-1-phenyl-1H...)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells at 1 uM by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50166283([5-(4-Methanesulfonyl-phenyl)-2-methyl-1-phenyl-1H...)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of COX1 in human whole blood assessed as thromboxane B2 production by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50166283([5-(4-Methanesulfonyl-phenyl)-2-methyl-1-phenyl-1H...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50166283([5-(4-Methanesulfonyl-phenyl)-2-methyl-1-phenyl-1H...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 1 in murine J774 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50166283([5-(4-Methanesulfonyl-phenyl)-2-methyl-1-phenyl-1H...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 2 in murine J774 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50166283([5-(4-Methanesulfonyl-phenyl)-2-methyl-1-phenyl-1H...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50166283([5-(4-Methanesulfonyl-phenyl)-2-methyl-1-phenyl-1H...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX1-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50166283([5-(4-Methanesulfonyl-phenyl)-2-methyl-1-phenyl-1H...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells at 10 uM by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50166283([5-(4-Methanesulfonyl-phenyl)-2-methyl-1-phenyl-1H...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX-1-mediated PGE2 production in arachidonic acid-stimulated mouse J774 cells incubated for 15 mins prior to arachidonic acid-challeng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50166283([5-(4-Methanesulfonyl-phenyl)-2-methyl-1-phenyl-1H...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed