BDBM50165274 8-(2-Bromo-5-methoxy-phenylsulfanyl)-9-pent-4-ynyl-9H-purin-6-ylamine::CHEMBL192145

SMILES COc1ccc(Br)c(Sc2nc3c(N)ncnc3n2CCCC#C)c1

InChI Key InChIKey=PZOOXEJSALVBGI-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50165274   

TargetHeat shock protein HSP 90-alpha(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165274(8-(2-Bromo-5-methoxy-phenylsulfanyl)-9-pent-4-ynyl...)
Affinity DataEC50:  2.95E+4nMAssay Description:Effective concentration of compound against heat shock protein HSP90 determined in normal heart cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165274(8-(2-Bromo-5-methoxy-phenylsulfanyl)-9-pent-4-ynyl...)
Affinity DataEC50:  1.44E+4nMAssay Description:Effective concentration of compound against heat shock protein HSP90 determined in normal brain cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165274(8-(2-Bromo-5-methoxy-phenylsulfanyl)-9-pent-4-ynyl...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of Hsp90 protein as degradation of HER2 kinase in SKBr3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165274(8-(2-Bromo-5-methoxy-phenylsulfanyl)-9-pent-4-ynyl...)
Affinity DataEC50:  70nMAssay Description:Displacement of 5 nM GM-BODIPY from mouse heat shock protein HSP90-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165274(8-(2-Bromo-5-methoxy-phenylsulfanyl)-9-pent-4-ynyl...)
Affinity DataEC50:  2.76E+4nMAssay Description:Effective concentration of compound against heat shock protein HSP90 determined in normal lung cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed