BDBM50165264 8-(2-Chloro-3,4,5-trimethoxy-phenylsulfanyl)-2-fluoro-9-(2-isopropoxy-ethyl)-9H-purin-6-ylamine::CHEMBL191786

SMILES COc1cc(Sc2nc3c(N)nc(F)nc3n2CCOC(C)C)c(Cl)c(OC)c1OC

InChI Key InChIKey=LJXZFKAGNMPIEM-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50165264   

TargetHeat shock protein HSP 90-alpha(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165264(8-(2-Chloro-3,4,5-trimethoxy-phenylsulfanyl)-2-flu...)
Affinity DataEC50:  160nMAssay Description:Displacement of 5 nM GM-BODIPY from mouse heat shock protein HSP90-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165264(8-(2-Chloro-3,4,5-trimethoxy-phenylsulfanyl)-2-flu...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of Hsp90 protein as degradation of HER2 kinase in SKBr3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165264(8-(2-Chloro-3,4,5-trimethoxy-phenylsulfanyl)-2-flu...)
Affinity DataEC50: >7.50E+4nMAssay Description:Effective concentration of compound against heat shock protein HSP90 determined in normal lung cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165264(8-(2-Chloro-3,4,5-trimethoxy-phenylsulfanyl)-2-flu...)
Affinity DataEC50:  2.67E+4nMAssay Description:Effective concentration of compound against heat shock protein HSP90 determined in normal heart cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165264(8-(2-Chloro-3,4,5-trimethoxy-phenylsulfanyl)-2-flu...)
Affinity DataEC50:  7.67E+4nMAssay Description:Effective concentration of compound against heat shock protein HSP90 determined in normal brain cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed