BDBM50162157 1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-(4-methoxy-phenyl)-urea::CHEMBL179603

SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)cc1

InChI Key InChIKey=UQLOTEZFDHTNMJ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50162157   

TargetVascular endothelial growth factor receptor 2(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162157(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162157(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of platelet-derived growth factor receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50162157(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162157(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human VEGFR-2-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162157(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162157(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50162157(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed