BDBM50161831 CHEMBL3793932::US9505736, (1S,2S,3S)-1-Fluoro-N-hydroxy-2-phenyl- 3-(4-(4-(trifluoromethyl)pyrimidin-2- yl)phenyl)cyclopropanecarboxamide

SMILES ONC(=O)[C@]1(F)[C@@H]([C@H]1c1ccc(cc1)-c1nccc(n1)C(F)(F)F)c1ccccc1

InChI Key InChIKey=DDTXYXHMSVMLET-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50161831   

TargetHistone deacetylase 4 [648-729,745-1057](Human)
Chdi Foundation

US Patent
LigandPNGBDBM50161831(US9505736, (1S,2S,3S)-1-Fluoro-N-hydroxy-2-phenyl-...)
Affinity DataIC50: 40nMpH: 8.0 T: 2°CAssay Description:The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2017
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
Biofocus

Curated by ChEMBL
LigandPNGBDBM50161831(US9505736, (1S,2S,3S)-1-Fluoro-N-hydroxy-2-phenyl-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of HDAC4 catalytic domain (unknown origin) using Boc-Lys(TFA)-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2017
Entry Details Article
PubMed