BDBM50158394 CHEMBL3780645

SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I

InChI Key InChIKey=OFYWNYOFFZRGTD-UHFFFAOYSA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50158394   

TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158394(CHEMBL3780645)
Affinity DataIC50: 324nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158394(CHEMBL3780645)
Affinity DataEC50:  0.400nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158394(CHEMBL3780645)
Affinity DataEC50:  31nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158394(CHEMBL3780645)
Affinity DataIC50: 69nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158394(CHEMBL3780645)
Affinity DataEC50:  5.90nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158394(CHEMBL3780645)
Affinity DataEC50:  5nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed