BDBM50157832 3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine-2,4-dione::CHEMBL361350

SMILES On1c(=O)[nH]c2sccc2c1=O

InChI Key InChIKey=NNWNTVVLCCOLEQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50157832   

TargetFlap endonuclease 1(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50157832(3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...)
Affinity DataIC50: 0.0250nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA excision repair protein ERCC-5(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50157832(3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...)
Affinity DataIC50: 0.101nMAssay Description:Inhibitory concentration against the xeroderma pigmentosum GMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFlap endonuclease 1(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50157832(3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...)
Affinity DataIC50: 9nMAssay Description:Inhibition of FEN1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDeoxyribonuclease-1(Human)
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50157832(3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DNAse1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGag-Pol polyprotein(HIV-1)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50157832(3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of polymerase activity of recombinant HIV1 reverse polymerase assessed as reduction in extension of an 18 nucleotide DNA primer using temp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50157832(3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...)
Affinity DataIC50: 200nMAssay Description:Inhibition of RNH activity of recombinant HIV1 reverse transcriptase RNase H assessed as reduction in internal cleavage of RNA strand using RNA/DNA d...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50157832(3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of HIV1 integrase pre-incubated for 10 mins before DNA substrate addition and measured after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTripartite terminase subunit 3(HHV-5)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50157832(3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Human Cytomegalovirus C-terminal UL89 phosphorylation using (5-tcggtgcgggcctcttcgctattacgccagctggcgaaagggggatgtgctgcaaggcga as a substr...More data for this Ligand-Target Pair
In DepthDetails
PubMed