BDBM50156670 2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidazole::4,5,6,7-TETRABROMO-N,N-DIMETHYL-1H-BENZIMIDAZOL-2-AMINE::CHEMBL376505

SMILES CN(C)c1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1

InChI Key InChIKey=SLPJGDQJLTYWCI-UHFFFAOYSA-N

Data  8 KI  9 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50156670   

TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
University of Western Ontario

LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataIC50: 484nMAssay Description:To determine the IC50 value of each inhibitor, reactions were initiated by addition of 154 pM NQO2 to a reaction buffer containing 150 μM SCDP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2015
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataIC50: 2.38E+3nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of MAPKAPK1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataIC50: 3.57E+3nMAssay Description:Inhibition of SGKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of MKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataIC50: 120nMAssay Description:Inhibition of DYRK1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
University of Western Ontario

LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataKd:  36.4nMAssay Description:To assess direct binding of inhibitors to oxidized NQO2 (NQO2ox), fluorescence quenching of FAD was monitored with an excitation wavelength of 350 nm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2015
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataIC50: 500nMAssay Description:Inhibition of rat liver CK2 phosphorylation using RRRADDSDDDDD as substrate in presence of [32p]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataIC50: 400nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant GST-tagged CK-2 using RRRADDSDDDDD as substrate incubated for 5 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCasein kinase II subunit alpha(Human)
Warsaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataKi:  40nMAssay Description:Binding affinity to CK2alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataKi:  40nMAssay Description:Inhibition of CK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Warsaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataKi:  97nMAssay Description:Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha'(Human)
The John Paul Ii Catholic University of Lublin

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataKi:  112nMAssay Description:Inhibition of human CK2 alpha' catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha'(Human)
The John Paul Ii Catholic University of Lublin

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataKi:  133nMAssay Description:Inhibition of human CK2 alpha' catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Warsaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataKi:  139nMAssay Description:Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataKi:  300nMAssay Description:Inhibition of rat liver CK2 phosphorylation using RRRADDSDDDDD as substrate in presence of [32p]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCasein kinase II subunit alpha(Human)
Warsaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataKi:  4.50E+3nMAssay Description:Inhibition of CK2alpha in human PLC1 cells using (Arg)3(Glu)3Thr(Glu)3 as substrate after 24 hrs in presence of [32P]gammaGTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed