BDBM50154286 CHEMBL3774910::US10106508, Compound II-4

SMILES COc1cccc(Nc2ncnc3cc4OCC(=O)N(CCCN5CCOCC5)c4cc23)c1

InChI Key InChIKey=WOHFHMIOTRFMRH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50154286   

TargetEpidermal growth factor receptor(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50154286(CHEMBL3774910 | US10106508, Compound II-4)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wildtype EGFR (unknown origin) preincubated for 30 mins followed by addition of 2x ATP-substrate mixture measured after 1 hr by Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50154286(CHEMBL3774910 | US10106508, Compound II-4)
Affinity DataIC50: 200nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM50154286(CHEMBL3774910 | US10106508, Compound II-4)
Affinity DataIC50: 1.00E+3nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
Go to US Patent