BDBM50153334 CHEMBL3774545::US10179769, Example 39::US10807956, Example 39::US11214542, Example 39::US11639333, Example 39::US9611221, Example 39::US9725441, Example 39::US9828343, Example 39

SMILES Cc1ccc(CNc2cnccc2C(O)=O)s1

InChI Key InChIKey=RFUZGPWCXINBNW-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50153334   

TargetLysine-specific demethylase 4C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153334(CHEMBL3774545 | US9611221, Example 39 | US10179769...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of full length human HALO-tagged KDM4C expressed in human U2OS cells assessed as level of H3K9Me3 demethylation incubated overnight by Hoe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153334(CHEMBL3774545 | US9611221, Example 39 | US10179769...)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM4C (unknown origin) using H3K9Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire mass spectrometric analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM50153334(CHEMBL3774545 | US9611221, Example 39 | US10179769...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM50153334(CHEMBL3774545 | US9611221, Example 39 | US10179769...)
Affinity DataIC50: 100nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetLysine-specific demethylase 4C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153334(CHEMBL3774545 | US9611221, Example 39 | US10179769...)
Affinity DataIC50: 100nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM50153334(CHEMBL3774545 | US9611221, Example 39 | US10179769...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM50153334(CHEMBL3774545 | US9611221, Example 39 | US10179769...)
Affinity DataIC50: 100nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM50153334(CHEMBL3774545 | US9611221, Example 39 | US10179769...)
Affinity DataIC50: 100nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM50153334(CHEMBL3774545 | US9611221, Example 39 | US10179769...)
Affinity DataIC50: 100nMAssay Description:Jarid1A: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM50153334(CHEMBL3774545 | US9611221, Example 39 | US10179769...)
Affinity DataIC50: 100nMAssay Description:Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent

TargetLysine-specific demethylase 4C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153334(CHEMBL3774545 | US9611221, Example 39 | US10179769...)
Affinity DataIC50: 100nMAssay Description:JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent