BDBM50153174 6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)-4'-(trifluoromethoxy)biphenyl-3-carbonitrile::6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-4''-trifluoromethoxy-biphenyl-3-carbonitrile::CHEMBL362881

SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N

InChI Key InChIKey=KUCIXFHIZYSMOM-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50153174   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153174(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50153174(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataEC50:  52nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50153174(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of [3H]GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50153174(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50153174(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of bovine GeranylgeranyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50153174(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataEC50:  52nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed