BDBM50153173 6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-3''-ethoxy-biphenyl-3-carbonitrile::6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-3'-ethoxy-biphenyl-3-carbonitrile::CHEMBL184707

SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N

InChI Key InChIKey=LOJYBMUXZXMFRE-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50153173   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153173(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50153173(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataEC50:  21.9nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50153173(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of [3H]GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed