BDBM50152916 (S)-1-Methyl-piperidine-2,3-dicarboxylic acid 3-(methoxy-amide) 2-{[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-amide}::CHEMBL183791

SMILES CONC(=O)[C@H]1CCCN(C)[C@@H]1C(=O)Nc1ccc(OCc2cc(C)nc3ccccc23)cc1

InChI Key InChIKey=ZJOWVJCIVPTYBC-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50152916   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152916((S)-1-Methyl-piperidine-2,3-dicarboxylic acid 3-(m...)
Affinity DataIC50: 20nMAssay Description:Effect on TNF-Alpha release in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152916((S)-1-Methyl-piperidine-2,3-dicarboxylic acid 3-(m...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of porcine Tumor necrosis factor- alpha converting enzyme (TACE, ADAM17)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152916((S)-1-Methyl-piperidine-2,3-dicarboxylic acid 3-(m...)
Affinity DataKi: >2.10E+3nMAssay Description:Inhibition of Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152916((S)-1-Methyl-piperidine-2,3-dicarboxylic acid 3-(m...)
Affinity DataKi: >3.30E+3nMAssay Description:inhibition of Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152916((S)-1-Methyl-piperidine-2,3-dicarboxylic acid 3-(m...)
Affinity DataKi: >4.90E+3nMAssay Description:Inhibition of Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed